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標題 【演講公告】From place cell to behavior: Functional processing along the hippocampus longitudinal axis
發佈日期 2017-04-24
內容

演講資訊:
日期:5月16日下午5點 10分
地點:社科院五樓玻璃屋
演講者:
Shang Lin (Tommy) Lee,
Ph.D. student, Department of Psychological Sciences
University of Connecticut

題目:
From place cell to behavior: Functional processing along the hippocampus longitudinal axis

摘要:
Episodic memory involves the storage and retrieval of details from a particular event. Remembering an experience, such as giving a talk entails remembering "what" happened, "where" that event occurred (e.g. National Cheng Kung University), and "when" it occurred (e.g. May 2017). Unlike humans that can self-report, studying the "when" aspect of spatial navigation in rodents has proven more difficult. My first study also included "when," by teaching rats a spatial sequential order task using a radial arm water maze.

The hippocampus has been linked to episodic memories and spatial navigation. However, the hippocampus is not a homogenous structure, it has dorsal and ventral regions that differ in their internal and external connectivity. Almost all rodent research has focused on the more accessible dorsal hippocampus, far less is known regarding the function of the ventral region. My second study determined the relative contributions of the dorsal and ventral parts of the hippocampus on a spatial reference memory water maze task. Individual hippocampal neurons fire in specific physical locations, generating a representation or map of the environment. These "place cells" show spatial tuning when rats traverse an (in humans: virtual) environment. However, if the environment or behavioral context is altered, a place cell can change its firing pattern or "remap." My current project investigates the phenomenon of remapping by recording dorsal and ventral place cell activity as a rat experiences a familiar and changed environment..