2020/6/17
Gut microbiota regulate social behavior via stress response pathways in the brain
演講相關內容如下：
時間：4/17（五）13：10
地點：社科院北棟2樓心理系階梯教室
講題：Gut microbiota regulate social behavior via stress response pathways in the brain
講者：吳偉立老師 （成功大學生理學科暨研究所助理教授）
個人簡介或CV：如附件
摘要：
Social interaction among animals mediates essential functions including mating, nurturing, and defense, and is controlled by internal states and external cues. While the intestinal microbiome contributes to social performance in animals, gut-brain connections that regulate this complex behavior and their underlying neural basis remain poorly understood. Herein, we reveal that gut microbiota modulate specific brain regions related to canonical stress responses during social behavior paradigms in mice. Social deviation in germ-free (GF) and antibiotic-treated mice is associated with elevated levels of the stress hormone corticosterone, which is primarily produced via activation of the hypothalamus- pituitary-adrenal (HPA) axis. Accordingly, removal of the adrenal gland, antagonism of the glucocorticoid receptor, and pharmacological inhibition of corticosterone synthesis effectively correct social deficits triggered by the gut microbiome. Genetic ablation of the glucocorticoid receptor in specific brain regions and chemogenetic inactivation of neuronal populations in the paraventricular nucleus of the hypothalamus (PVN) dramatically rescue social impairments caused by microbiome depletion. Finally, we uncover that specific activation of corticotrophin-releasing hormone (CRH)-expressing neurons in the PVN is sufficient to induce social deficits in healthy mice. These discoveries demonstrate that the gut microbiome regulates social interactions by co-opting specific neuronal circuits that control stress responses, revealing a novel pathway by which gut-brain connections contribute to complex behaviors in animals.
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