2020/1/3
Endogenous and exogenous control of visuospatial selective attention in freely behaving mice
演講相關內容如下：
時間：1/3（五）13：10-
地點：社科院北棟2樓心理系階梯教室
講者：游文愷博士候選人 （美國約翰霍普金斯大學）
講題：Endogenous and exogenous control of visuospatial selective attention in freely behaving mice
個人簡介或CV：參考附件
摘要：
Visuospatial selective attention, the remarkable ability of animals to prioritize and preferentially process information at the most important location in their visual environment, is essential for adaptive behavior. It has been investigated almost exclusively in primates and primarily in head-fixed animals, limiting investigations into the neural circuit mechanisms of this critical executive function. Here, we report the development of two human-inspired, discrimination-based behavioral paradigms for studying visuospatial selective attention in unrestrained mice. In the ‘spatial probability’ task, we found enhanced accuracy, perceptual sensitivity, and rate of evidence accumulation at the location with higher probability of target occurrence, and opposite effects at the lower probability location. Together with video-based 3D head-tracking, these results demonstrated endogenous expectation-driven shifts of spatial attention. In the ‘flanker’ task, we found that a second stimulus presented with the target, but with conflicting information, caused switch-like decrements in accuracy and sensitivity as a function of its contrast, and slower evidence accumulation, demonstrating exogenous capture of spatial attention. These tasks for the rigorous study of visuospatial selective attention in freely behaving mice open a rich avenue for research into its neural circuit underpinnings.
敬請準時出席，謝謝。
時間：1/3（五）13：10-
地點：社科院北棟2樓心理系階梯教室
講者：游文愷博士候選人 （美國約翰霍普金斯大學）
講題：Endogenous and exogenous control of visuospatial selective attention in freely behaving mice
個人簡介或CV：參考附件
摘要：
Visuospatial selective attention, the remarkable ability of animals to prioritize and preferentially process information at the most important location in their visual environment, is essential for adaptive behavior. It has been investigated almost exclusively in primates and primarily in head-fixed animals, limiting investigations into the neural circuit mechanisms of this critical executive function. Here, we report the development of two human-inspired, discrimination-based behavioral paradigms for studying visuospatial selective attention in unrestrained mice. In the ‘spatial probability’ task, we found enhanced accuracy, perceptual sensitivity, and rate of evidence accumulation at the location with higher probability of target occurrence, and opposite effects at the lower probability location. Together with video-based 3D head-tracking, these results demonstrated endogenous expectation-driven shifts of spatial attention. In the ‘flanker’ task, we found that a second stimulus presented with the target, but with conflicting information, caused switch-like decrements in accuracy and sensitivity as a function of its contrast, and slower evidence accumulation, demonstrating exogenous capture of spatial attention. These tasks for the rigorous study of visuospatial selective attention in freely behaving mice open a rich avenue for research into its neural circuit underpinnings.
敬請準時出席，謝謝。
檔案下載 |
| ▪ wkyou_CV.pdf |